D-159404 - CAS 1158221-32-9

D-159404, as an allosteric inhibitor, demonstrates superior inhibitory effects on the full-length PDE 4D3 compared to its truncated form and exhibits higher cellular activity. This sets it apart from competitive inhibitors like roflumilast and cilomilast. These findings indicate that D-159404 and related compounds may offer valuable insights into PDE 4 pharmacology and serve as strong candidates for further study on cAMP signaling's impact on disease treatment.

1158180

C21H18ClFN2O2

384.83

O=C(N)NC1=CC=C(C=C1)CC=2C=CC(OC)=C(C3=CC=CC(Cl)=C3)C2F

-20°C

Ice Packs

Small Compound