D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) - CAS 157542-47-7

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins (1,4,5,6) -P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins (1,4,5,6) -P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins (1,4,5,6) -P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins (1,4,5,6) -P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins (1,4,5,6) -P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins (1,4,5,6) -P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins (1,4,5) -P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]

Calcium Channel, Others

Membrane transporter/Ion channel, Others, Metabolism

157488

C6H12Na4O18P4

588

[Na].O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O

-20°C

Ice Packs

Small Compound