D-myo-Inositol-1,4,6-triphosphate (sodium salt) - CAS 157380-18-2

D-myo-Inositol-1,4,6-phosphate (Ins (1,4,6) -P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins (1,4,5) -P3, is a second messenger produced in cells by phospholipase C (PLC) -mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins (1,4,5) -P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins (1,4,6) -P3 (tested as the meso compound) is 9-fold less potent than Ins (1,4,5) -P3 at initiating Ca2+ release when injected into Xenopus oocytes.

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157360

C6H12Na3O15P3

486.04

[Na].O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O

-20°C

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