D18 - CAS 2230218-36-5

D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively) . It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].

Others, TLR, PD-1/PD-L1

Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint, Others

2230177

C21H28N6

364.49

N(CCCC)C=1C2=C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)N=C(N)N1

-20°C

Ice Packs

Small Compound