D3/5-HT receptor modulator-1 - CAS 898532-85-9

D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.

Dopamine Receptor, 5-HT Receptor

GPCR/G Protein, Neuroscience

898438

C24H29N3O2

391.506

O=C(NCCCCN1CCN(C2=CC=CC(=C2)C)CC1)C=3OC=4C=CC=CC4C3

-20°C

Ice Packs

Small Compound