D359-0396 - CAS 1031977-31-7

D359-0396, an orally active NLRP3 inflammasome inhibitor, mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. The compound is effective in alleviating Experimental Autoimmune Encephalomyelitis (EAE) and enhances survival following septic shock in mice [1].

Pyroptosis, NOD-like Receptor (NLR)

Apoptosis, Immunology/Inflammation

1031977-31-7

C24H24N4O2

400.47

O=C1C2=CN3C=4C=CC=CC4NC(C5=CC=C(C=C5)C(C)C)C3=C2N(C(=O)N1C)C

-20°C

Ice Packs

Small Compound