D3S-001 - CAS 2914919-85-8

D3S-001 is an orally effective KRAS inhibitor. It suppresses the proliferation of the KRASG12C mutants H358 and MIA-PA-CA-2 with IC50 values of 0.6 and 0.44 nM, respectively. D3S-001 exhibits good metabolic stability across multiple species in hepatocytes, liver microsomes, plasma, and whole blood. Additionally, it demonstrates favorable pharmacokinetic properties and antitumor activity in mice.

Ras, Kras

MAPK

2914919-85-8

C32H35F6N7O3

679.66

C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C)=CC(N)=C3F)N4C[C@H](CC#N)N(C(C(=C)F)=O)CC4)[C@@]56N(C[C@H](F)C5)CCC6

-20°C

Ice Packs

Small Compound