Dacomitinib – Molfinity

Molfinity

Product Details

Bioactivity
Dacomitinib (PF299) (PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
Target
EGFR, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Apoptosis
CAS Number
1110778
Purity
>99.99%
Molecular Formula
C24H25ClFN5O2
Molecular Weight
469.94
SMILES
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound