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Molfinity

Dacomitinib hydrate - CAS 1042385-75-0

Dacomitinib hydrate - CAS 1042385-75-0

MF-0014452-01

$42.14 USD
$42.14 USD
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Product Details

  • Bioactivity

    Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

  • Target

    EGFR

  • Related Pathways

    JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors

  • CAS Number

    1042310

  • Purity

    0.9952

  • Molecular Formula

    C24H27ClFN5O3

  • Molecular Weight

    487.96

  • SMILES

    O.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound