Dactinomycin - CAS 50-76-0

Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.

DNA/RNA Synthesis, Autophagy, Apoptosis, Antibacterial, Antibiotic

Microbiology/Virology, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Apoptosis, Autophagy

50-76-0

0.997

C62H86N12O16

1255.42

C(N[C@@H]1C(=O)N[C@H](C(C)C)C(=O)N2[C@@](CCC2)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@@H](C)C)C(=O)O[C@@H]1C)[H])(=O)C=3C=4C(OC=5C(N4)=C(C(N[C@@H]6C(=O)N[C@H](C(C)C)C(=O)N7[C@@](CCC7)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@H](C)C)C(=O)O[C@@H]6C)[H])=O)C=CC5C)=C(C)C(=O)C3N

-20°C

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Natural Product