Dactolisib - CAS 915019-65-7

Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR, with IC50 values of 4 nM for p110α, 5 nM for p110γ, 7 nM for p110δ, 75 nM for p110β, and 20.7 nM for mTOR.

Autophagy, mTOR, ATM/ATR, PI3K

Autophagy, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

914947

0.9985

C30H23N5O

469.54

O=C1N(C=2C=3C(N=CC2N1C)=CC=C(C3)C4=CC5=C(N=C4)C=CC=C5)C6=CC=C(C(C#N)(C)C)C=C6

-20°C

Ice Packs

Small Compound