Dalbergioidin - CAS 30368-42-4

Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.

ROS, PI3K, Akt, Tyrosinase, TGF-beta/Smad

Immunology/Inflammation, Cytoskeletal Signaling, Proteases/Proteasome, PI3K/Akt/mTOR signaling, Stem Cells

30322

C15H12O6

288.25

Oc1ccc(C2COc3cc(O)cc(O)c3C2=O)c(O)c1

-20°C

Ice Packs

Natural Product