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Dalpiciclib - CAS 1637781-04-4

Dalpiciclib - CAS 1637781-04-4

MF-0048622-01

$148.50 USD
$148.50 USD
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Product Details

  • Bioactivity

    Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest.

  • Target

    CDK

  • Related Pathways

    Cell Cycle/Checkpoint

  • CAS Number

    1637781-04-4

  • Purity

    0.9969

  • Molecular Formula

    C25H30N6O2

  • Molecular Weight

    446.54

  • SMILES

    O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)C4CCNCC4)N2)C5CCCC5

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound