Danusertib - CAS 827318-97-8

Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed.

Autophagy, Aurora Kinase, c-RET, FGFR, Bcr-Abl, Trk receptor

Tyrosine Kinase/Adaptors, Autophagy, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Cytoskeletal Signaling, Angiogenesis, Apoptosis

827318-97-8

0.9879

C26H30N6O3

474.55

CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1

-20°C

Ice Packs

Small Compound