DAP-81 - CAS 794466-17-4

DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.

Others, PLK

Cell Cycle/Checkpoint, Others

794445

C25H20N6O4

468.46

C(=O)(C1=C(NC=2C(N(=O)=O)=CN=C(NC3=CC=C(NC(C)=O)C=C3)N2)C=CC=C1)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound