Dasatinib hydrochloride - CAS 854001-07-3

Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride hydrochloride also induces Apoptosis and Autophagy.

Autophagy, Apoptosis, c-Kit, Src, Bcr-Abl

Autophagy, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, Cytoskeletal Signaling

854001-07-3

0.9998

C22H27Cl2N7O2S

524.47

Cl.Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1

-20°C

Ice Packs

Small Compound