Dasatinib monohydrate - CAS 863127-77-9

Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.

Apoptosis, Ephrin Receptor, Autophagy, Src, c-Kit, Bcr-Abl

Tyrosine Kinase/Adaptors, Apoptosis, Autophagy, Angiogenesis, Cytoskeletal Signaling

863041

>99.99%

C22H28ClN7O3S

506.03

n1cc(sc1Nc1nc(nc(N2CCN(CC2)CCO)c1)C)C(=O)Nc1c(cccc1C)Cl.O

-20°C

Ice Packs

Small Compound