DASK1 - CAS 3064086-31-0

DASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1) . It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.

ASK, PROTACs

PROTAC, Apoptosis

3064055

C38H38F2N10O8

800.77

O=C(NC1=NC(=CC=C1)C2=NN=CN2C(C)C)C3=CC(NC(=O)CCC(=O)NCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)=C(F)C=C3F

-20°C

Ice Packs

PROTAC