DB0614 - CAS 2769753-47-9

DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. This compound has potential applications in research on diseases or disorders caused by aberrant kinase activity [1].

AAK1 (AP2 associated kinase 1), Ferroptosis, PROTACs, CaMK, LIM Kinase, Aurora Kinase, Autophagy, CDK, SIK

PROTAC, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Neuroscience, Autophagy, PI3K/Akt/mTOR signaling, Apoptosis

2769697

C41H42N8O7S2

822.95

CS(=O)(=O)Nc1cccc(c1)-c1csc2cnc(Nc3ccc(cc3)N3CCN(CCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12

-20°C

Ice Packs

PROTAC