DB1113 - CAS 2769753-53-7

DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. This capability positions DB1113 as a valuable tool for research into diseases or disorders associated with aberrant kinase activity [1].

PROTACs, Ferroptosis, LIM Kinase, Autophagy, MAPK, Serine/threonin kinase, CDK, SIK, Bcr-Abl

Autophagy, Angiogenesis, MAPK, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Metabolism, Apoptosis, PROTAC, Cytoskeletal Signaling

2769693

C59H68F3N13O6S

1144.31

C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

-20°C

Ice Packs

PROTAC