DBET1 - CAS 1799711-21-9

DBET1 is a hybrid molecule that combines (+) -JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.

Epigenetic Reader Domain, PROTACs

PROTAC, Chromatin/Epigenetic

1799681

0.993

C38H37ClN8O7S

785.27

CC=1C2=C(N3C([C@H](CC(NCCCCNC(COC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

-20°C

Ice Packs

PROTAC