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DBPR112 - CAS 1226549-49-0

DBPR112 - CAS 1226549-49-0

MF-0000263-01

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Product Details

  • Bioactivity

    DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM for EGFRWT and 48 nM for EGFRL858R/T790M, capable of occupying the ATP-binding site and demonstrating significant antitumor efficacy.

  • Target

    EGFR

  • Related Pathways

    Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

  • CAS Number

    1226549-49-0

  • Purity

    0.9925

  • Molecular Formula

    C32H31N5O3

  • Molecular Weight

    533.62

  • SMILES

    CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1c(oc2ncnc(N[C@H](CO)c3ccccc3)c12)-c1ccccc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound