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Molfinity

DBPR728 - CAS 2702965-64-6

DBPR728 - CAS 2702965-64-6

MF-0147904-01

$1,383.80 USD
$1,383.80 USD
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Product Details

  • Bioactivity

    DBPR728, an acyl prodrug of 6K465, possesses fewer hydrogen bond donors and functions as an Aurora kinase inhibitor that targets MYC family cancer proteins, showing antitumor potential. It can effectively inhibit cancers overexpressing C-MYC and N-MYC, offering a 10-fold improvement in oral bioavailability over 6K465.

  • Target

    Aurora Kinase

  • Related Pathways

    Chromatin/Epigenetic, Cell Cycle/Checkpoint

  • CAS Number

    2702965-64-6

  • Molecular Formula

    C29H37ClFN9O2

  • Molecular Weight

    598.11

  • SMILES

    O=C(C=1C=CC=C(Cl)C1F)N2CCC(NC=3N=C(C=C(N3)N4CCN(CC)CC4)NC5=CC(=NN5C(=O)CC)C)CC2

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound