DBRD4-BD1 - CAS 2839318-19-1

DBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM) . Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables analysis of BRD4 biology without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional molecules, such as degraders with new E3 recruiting ligands or for additional probes beyond degraders.

Others, PROTACs, Epigenetic Reader Domain

PROTAC, Others, Chromatin/Epigenetic

2839298

C50H53F3N8O9

967

O(C=1N=C(C2=C(N=CN2C3CCN(CCOCCOCCNC(COC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)CC3)C7=CC=C(C(F)(F)F)C=C7)C=CN1)C8=CC(C(C)C)=CC=C8C

-20°C

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