DDO-8958 - CAS 3017180-18-3

DDO-8958 is an orally active and selective BET BD1 inhibitor, exhibiting a KD of 5.6 nM for BRD4 BD1. It shows low nanomolar inhibitory activity across all BET BD1 bromodomains except for BRDT BD1. DDO-8958 inhibits tumor cell proliferation and migration, induces apoptosis and cell cycle arrest, and demonstrates antitumor activity.

Epigenetic Reader Domain, Apoptosis

Apoptosis, Chromatin/Epigenetic

3017159

C22H22FN5O2

407.441

FC=1C(=CC(OCC2COC2)=CC1C=3C(=NN(C3C)C)C)C4=CC=NC=5N=CNC54

-20°C

Ice Packs

Small Compound