DDO3711 - CAS 2673364-10-6

DDO3711, a PP5-recruiting phosphatase recruitment chimera (PHORC), is created by chemically linking an apoptosis signal-regulated kinase 1 (ASK1) inhibitor with a PP5 activator. This compound selectively targets ASK1 (IC50=164.1 nM) over ASK2 (IC50 >20 μM), effectively dephosphorylating p-ASK1 T838 through PP5 recruitment. Exhibiting ASK1-dependent antiproliferative properties, DDO3711 demonstrates anti-cancer activity, making it a promising agent for research into the abnormal phosphorylation of oncoproteins.

MAPK, Others

MAPK, Others

2673348

C42H41N9O6

767.83

N(C(=O)C1=CC=C(C(NCCCCCCNC(=O)C2=CC=C(CC=3N=C(ON3)C4=CC(OC)=C(OC)C=C4)C=C2)=O)C=C1)C5=CN6C(=N5)C=CC(=C6)N7C=CN=C7

-20°C

Ice Packs

Small Compound