Debio 0617B - CAS 1332329-27-7

Debio 0617B is a multi-kinase inhibitor that reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. debio 0617B targets key kinases upstream of STAT3/STAT5 signalling, such as JAK, ABL, SRC and class III/V receptor tyrosine kinases. debio 0617B can be used to study STAT3 driven solid tumours.

Others, JAK, STAT, Bcr-Abl

Others, Chromatin/Epigenetic, Stem Cells, Cytoskeletal Signaling, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

1332295

C28H23ClF3N7O2

581.98

ClC=1C(N2CC=3C(CC2)=NC(NC4=CC=C(C(NC)=O)C=C4)=NC3)=CC(NC(=O)C5=CC(C(F)(F)F)=CC=N5)=CC1

-20°C

Ice Packs

Small Compound