DeFer-2 - CAS 3058911-16-0

DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM) . It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.

ROS, PROTACs, Pyroptosis, Caspase

PROTAC, Immunology/Inflammation, Apoptosis, Proteases/Proteasome

3058895

C44H69N5O5S

780.11

C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1

-20°C

Ice Packs

PROTAC