DEG-35 - CAS 2734910-37-1

DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML) .

Casein Kinase, IKZF, Molecular Glues

PROTAC, Metabolism, Stem Cells, Immunology/Inflammation

2734872

C25H21N3O5

443.45

O=C(NC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=C5C=C(OC)C=CC5=C4

-20°C

Ice Packs

PROTAC