Dehydrobruceine B - CAS 53730-90-8

Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing factor (AIF) and Bax while inhibiting Keap1-Nrf2 [1].

Nrf2, Others, Apoptosis, Bcl-2 Family

Apoptosis, Others, Immunology/Inflammation

53632

C23H26O11

478.45

C(OC)(=O)[C@]12[C@]3([C@]4([C@@]([C@]5(C)C(C[C@]4(OC(=O)[C@@H]3OC(C)=O)[H])=C(C)C(=O)C(O)=C5)([C@@H](O)[C@@H]1O)[H])CO2)[H]

-20°C

Ice Packs

Natural Product