Dehydrocorydaline - CAS 30045-16-0

1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose (IC50= 34.914 ug/mL) . 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

Autophagy, Parasite, PARP, Caspase, Bcl-2 Family, p38 MAPK

MAPK, DNA Damage/DNA Repair, Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, Autophagy, Microbiology/Virology

30029

0.9984

C22H24NO4

366.43

CC1=C2C=3C(=CC(OC)=C(OC)C3)CC[N+]2=CC=4C1=CC=C(OC)C4OC

-20°C

Ice Packs

Natural Product