Dehydroglyasperin C - CAS 199331-35-6

Dehydroglyasperin C is a potent NAD (P) H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways.

TNF, Nrf2, PI3K, DNA/RNA Synthesis, JNK, COX, Autophagy, ERK, p38 MAPK, NADPH, IκB/IKK, NF-κB, Akt

Apoptosis, Cytoskeletal Signaling, Autophagy, MAPK, Neuroscience, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism, NF-κB, Immunology/Inflammation

199290

C21H22O5

354.4

COc1c(CC=C(C)C)c(O)cc2OCC(=Cc12)c1ccc(O)cc1O

-20°C

Ice Packs

Natural Product