Desmorpholinyl Quizartinib-PEG2-COOH - CAS 2292116-14-2

Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM.

Others, Target Protein Ligand-Linker Conjugate

Others, PROTAC

2292100

C30H33N5O7S

607.68

CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCOCCOCCC(O)=O)ccc32)no1

-20°C

Ice Packs

PROTAC