DFPQ - CAS 911678-60-9

DFPQ is a powerful and selective β-arrestin-biased negative allosteric modulator (NAM) targeting the β2-adrenergic receptor. It specifically inhibits the interaction of β-arrestin with β2AR without altering β-agonist-induced cAMP production. Additionally, DFPQ reduces functional desensitization of the β2AR in airway smooth muscle, enhancing β-agonists' capacity to maintain bronchorelaxation and curbing cell migration during prolonged β-agonist treatment.

911678-60-9

C20H20F2N4

354.4

FC1=CC=C(C=C1F)NC=2N=C3C=CC=CC3=C(N2)NC4CCCCC4

-20°C

Ice Packs

Small Compound