DHODH-IN-25 - CAS 2619531-95-0

DHODH-IN-25 (Compound 25) serves as an orally active inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting a potent IC50 of 5.4 nM against human DHODH. It is applicable in research related to acute myeloid leukemia (AML) [1].

Dehydrogenase, DNA/RNA Synthesis

Cell Cycle/Checkpoint, Metabolism, DNA Damage/DNA Repair

2619531-95-0

C22H19ClF5N3O5

535.85

O([C@H](C(F)(F)F)C)C1=C(C(NC2=C(Cl)C=CC=C2F)=O)C=C(F)C(NC(=O)N3C(CO)CCC3=O)=C1

-20°C

Ice Packs

Small Compound