DI-87 - CAS 2107280-55-5

DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding. DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, which reduces the production of dNTP and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.

Others, DNA/RNA Synthesis

DNA Damage/DNA Repair, Others, Cell Cycle/Checkpoint

2107220

0.9976

C23H30N6O3S2

502.65

[C@@H](SC=1N=C(N)C=C(N)N1)(C)C=2N=C(SC2C)C3=CC(OCCN4CCOCC4)=C(OC)C=C3

-20°C

Ice Packs

Small Compound