DIBAC-GGFG-NH2CH2-Dxd - CAS 2758875-01-1

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a derivative of Camptothecin, serves as a linker-payload for protein-agent conjugates [1]. It is utilized as a payload in the antibody-coupling drug ADC (DS-8201a) . Additionally, this compound functions as a click chemistry reagent due to its DBCO group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-group-containing molecules.

Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related

2758875-01-1

C61H58FN9O12

1128.16

N(C(COCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCC(=O)N2C=3C(C#CC=4C(C2)=CC=CC4)=CC=CC3)=O)=O)=O)=O)=O)=O)[C@@H]5C6=C7C(C=8N(C7)C(=O)C9=C(C8)[C@](CC)(O)C(=O)OC9)=NC=%10C6=C(CC5)C(C)=C(F)C%10

-20°C

Ice Packs

Small Compound