Dichotomine C - CAS 755036-45-4

Dichotomine C ((R) - (-) -Dichotomine C) is a β-carboline alkaloid with anti-allergic properties. It inhibits the release of β-hexosaminidase from RBL-2H3 cells with an IC50 of 62 μM. Additionally, it suppresses antigen IgE-mediated release of TNF-α and IL-4 in RBL-2H3 cells, with IC50 values of 19 μM and 15 μM, respectively. This compound is applicable in the research of type I hypersensitivity reactions.

Interleukin, TNF, glycosidase

Metabolism, Apoptosis, Immunology/Inflammation

755036-45-4

C15H14N2O4

286.28

[C@@H](CO)(O)C1=C2C(C=3C(N2)=CC=CC3)=CC(C(OC)=O)=N1

-20°C

Ice Packs

Natural Product