Dideoxy-amanitin - CAS 58255-46-2

Dideoxy-amanitin (compound 2), a derivative of α-Amanitin, functions as a potent, selective allosteric inhibitor of RNA polymerase II, demonstrating an inhibition concentration (IC50) of 74.2 nM [1].

DNA/RNA Synthesis, ADC Cytotoxin

Antibody-drug Conjugate/ADC Related, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

58207

C39H54N10O12S

886.97

[H][C@@]12C[C@@H](O)CN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CSc3[nH]c4ccccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1

-20°C

Ice Packs

Small Compound