DIF-3 - CAS 113411-17-9

DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1].

GSK-3, Wnt/beta-catenin, CDK

PI3K/Akt/mTOR signaling, Stem Cells, Cytoskeletal Signaling, Cell Cycle/Checkpoint

113385

0.9957

C13H17ClO4

272.72

CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O

-20°C

Ice Packs

Small Compound