Dihydrocapsaicin - CAS 19408-84-5

Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. Dihydrocapsaicin is an activator of VR1.

ROS, PI3K, Apoptosis, Akt, Bcl-2 Family, Caspase, Reactive Oxygen Species, TRP/TRPV Channel

Cytoskeletal Signaling, Metabolism, Immunology/Inflammation, Apoptosis, NF-κB, Membrane transporter/Ion channel, Proteases/Proteasome, PI3K/Akt/mTOR signaling

19319

0.9994

C18H29NO3

307.43

C(NC(CCCCCCC(C)C)=O)C1=CC(OC)=C(O)C=C1

-20°C

Ice Packs

Natural Product