β, β-Dimethylacrylshikonin - CAS 24502-79-2

1. β, β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H (22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.

HIF/HIF Prolyl-Hydroxylase, ERK, Gamma-secretase, Bcl-2 Family, Apoptosis, NO Synthase

Neuroscience, Metabolism, Stem Cells, MAPK, Chromatin/Epigenetic, Immunology/Inflammation, Proteases/Proteasome, Apoptosis

24502-79-2

0.9997

C21H22O6

370.396

O=C1C=2C(C(=O)C=C1[C@H](OC(C=C(C)C)=O)CC=C(C)C)=C(O)C=CC2O

-20°C

Ice Packs

Natural Product