Diminutol - CAS 361431-33-6

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.

Others, Microtubule Associated

Cytoskeletal Signaling, Others

361392

C19H26N6OS

386.51

S(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](C(C)C)CO)=N1)C3=CC(N)=CC=C3

-20°C

Ice Packs

Small Compound