Divarasib adipate - CAS 2762240-36-6

Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].

Kras, Ras

MAPK, GPCR/G Protein

2762240-36-6

C35H42ClF4N7O6

768.2

C(CCC(O)=O)CC(O)=O.FC=1C2=C(C(=NC(OCC3N(C)CCC3)=N2)N4C(C)CN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(C(F)(F)F)C(C)=CC(N)=N5

-20°C

Ice Packs

Small Compound