DLK-IN-1 - CAS 1620574-24-4

DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration exceeds the concentration required for DLK inhibition in the brain, so it has good tolerance Acceptability.

MAPK, DNA Alkylation

MAPK, DNA Damage/DNA Repair

1620546

C20H24F3N5O2

423.43

[H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1

-20°C

Ice Packs

Small Compound