DM-4103 - CAS 1346599-56-1

DM-4103 is a primary metabolite of Tolvaptan, predominantly metabolized by the CYP3A4 enzyme in the liver. In SCHH cells, DM-4103 inhibits the human liver transport proteins NTCP, BSEP, MRP2, MRP3, and MRP4 with IC50 values of 16.3, 4.15, 51.0, 44.6, and 4.26 μM, respectively, and affects bile acid transport. DM-4103 is applicable for research in autosomal dominant polycystic kidney disease (ADPKD) .

P-gp

Membrane transporter/Ion channel, Neuroscience

1346542

C26H23ClN2O5

478.92

O=C(O)CCC(=O)C1=CC(Cl)=CC=C1NC(=O)C2=CC=C(C=C2C)NC(=O)C=3C=CC=CC3C

-20°C

Ice Packs

Small Compound