DM-4107 - CAS 1346599-75-4

DM-4107 is a primary metabolite of Tolvaptan, primarily metabolized by the CYP3A4 enzyme in the liver. In SCHH cells, DM-4107 inhibits the human liver transport proteins NTCP, BSEP, MRP3, and MRP4, with IC50 values of 95.6, 119, 61.2, and 37.9 μM respectively, affecting bile acid transport. It is applicable for research on autosomal dominant polycystic kidney disease (ADPKD) .

P-gp

Membrane transporter/Ion channel, Neuroscience

1346520

C26H25ClN2O5

480.94

O=C(O)CCC(O)C1=CC(Cl)=CC=C1NC(=O)C2=CC=C(C=C2C)NC(=O)C=3C=CC=CC3C

-20°C

Ice Packs

Small Compound