DM3-SMe - CAS 796073-70-6

DM3-SMe, a maytansine derivative and tubulin inhibitor, acts as the cytotoxic component in antibody-drug conjugates (ADCs) . It can bind to antibodies through disulfide bonds or stable thioether bonds and demonstrates high in vitro cytotoxic activity with an IC50 of 0.0011.

Microtubule Associated, ADC Cytotoxin

Antibody-drug Conjugate/ADC Related, Cytoskeletal Signaling

795997

C38H54ClN3O10S2

812.43

C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCC(SSC)C)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]

-20°C

Ice Packs

Small Compound