DMCL1-2 - CAS 2351218-88-5

DMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

Others, PROTACs, Apoptosis, Bcl-2 Family

PROTAC, Apoptosis, Others

2351218-88-5

C61H66N10O12S

1163.3

O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(CC5)S(=O)(=O)N(C)C)C)C)C2N1CCN6CCN(C(=O)COC7=CC=CC=8C(=O)N(C(=O)C78)C9C(=O)NC(=O)CC9)CC6)CCCOC%10=CC=CC=%11C=CC=CC%10%11

-20°C

Ice Packs

PROTAC