DN-108 - CAS 195604-21-8

DN-108, a thiazolidinedione derivative, acts as an orally active peroxisome proliferator-activated receptor γ (PPARγ) agonist with antidiabetic properties. It improves hyperglycemia, hypertriglyceridemia, and hyperinsulinemia in diabetic mouse models. DN-108 enhances tissue glucose uptake (e.g., increases 2-deoxyglucose uptake in L6 muscle cells) and inhibits fatty acid synthase activity, making it a promising candidate for type 2 diabetes research.

PPAR

DNA Damage/DNA Repair, Metabolism

195575

C20H18N2O3S

366.43

O=C1SC(C(=O)N1)CC2=CC=C(C=C2)NC(=O)C3(C=4C=CC=CC4)CC3

-20°C

Ice Packs

Small Compound